Airway granulocytes potential CF biomarker for fungal lung disease By Kirsty Oswald, medwireNews Reporter Experts have discovered that accumulation in the airways of CXCR4+ granulocytes is connected with chronic colonisation by the fungus Aspergillus fumigatus. Furthermore, in the scholarly study, degrees of the granulocytes correlated with lung disease intensity in sufferers with cystic fibrosis , leading the united team to suggest they could serve, not merely as a biomarker, but also as a therapeutic target in the disease health . The analysis included 40 sufferers with CF and two control groupings: eight sufferers with non-CF bronchiectasis and 10 healthy controls. The team found that the %age of CXCR4+ granulocytes was increased in CF sufferers in both peripheral blood and the airways.
In addition, it suggests that new medications that interfere with the role of anchoring proteins are feasible therapeutic interventions to treat chronic illnesses such as diabetes.’ The researchers used imaging techniques and also genetic modification of isolated insulin-secreting cells and entire mice to investigate the effect of anchoring proteins on glucose rate of metabolism and insulin discharge. Mice that lacked the gene for the AKAP150 anchoring protein produced less insulin from beta cells in the islets of Langerhans. However, they coped better with limited amounts of hormone due to elevated sensitivity to insulin in the target tissues . The scientists showed that these effects are because of a seven-amino-acid sequence in the anchor protein that straight interacts with the surface of the phosphatase enzyme.