Exposure can lead to loss of awareness, convulsions, paralysis, and respiratory failing resulting in death. The nerve agent works similarly to pesticide and was originally created in the first 1950s. The nation’s entire initial stockpile of approximately 4,400 tons of VX was produced at Newport Chemical Depot between 1961 and 1969. Newport’s production facility was destroyed in 2006. VX nerve agent was never used in combat by the United States. The elimination of this deadly chemical substance agent from each site’s stockpile is a relief to the stockpile communities, and an indicator of our dedication to other countries as we move one stage nearer to a safer globe, said Mr.Hoffman, M.D., Cees G.M. Kallenberg, M.D., Ph.D., E. William St. Clair, M.D., Barri J. Fessler, M.D., Linna Ding, M.D., Ph.D., Lisa Viviano, R.N., Nadia K. Tchao, M.D., Deborah J. Phippard, Ph.D., Adam L. Asare, Ph.D., Noha Lim, Ph.D., David Ikle, Ph.D., Brett Jepson, M.S., Paul Brunetta, M.D., Nancy B. Allen, M.D., Fernando C. Fervenza, M.D., Ph.D., Duvuru Geetha, M.D., Karina Keogh, M.B., B.Ch., Eugene Y. Kissin, M.D., Paul A. Monach, M.D., Ph.D., Tobias Peikert, M.D., Coen Stegeman, M.D., Ph.D., Steven R. Ytterberg, M.D., Tag Mueller, B.S., C.C.R.P., Lourdes P. Sejismundo, R.N., Kathleen Mieras, C.C.R.P., and John H. Rock, M.D., M.P.H.1,2 For four decades nearly, glucocorticoids and cyclophosphamide have been the standard therapy for the induction of remission.