The hope is that patients won’t have to suffer this kind or kind of trauma later on. New operative methods in cosmetic surgery enable surgeons to take care of huge defects after tumor treatment or because of pet bites with a far greater cosmetic result. In smaller wounds, the reconstruction can be done by the surgeon within a single operation. If more than a quarter of the nose provides been destroyed, the limitations of the method have already been reached: The patient will stay disfigured even after medical procedures. Better esthetic results could be reached by performing several surgical treatments in succession. However, occasionally a satisfactory result can be achieved only by way of amputation and subsequent reconstruction of the severely broken nose.. 7 years with out a nose Patients whose nose offers been destroyed by a injury or tumor carry a severe psychological and public burden.Methods Patients The Timing of Intervention in Acute Coronary Syndromes trial was a randomized, parallel-group, multicenter trial with blinded adjudication of outcomes. From 2003 through June 2008 April, a total of 3031 patients underwent randomization. The trial began as an investigator-initiated, randomized substudy of the Fifth Corporation to Assess Strategies in Ischemic Syndromes trial , that the first 1633 sufferers were recruited, with yet another 1398 patients recruited after the main OASIS-5 trial had ended.