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Over a period of 24 hours, the drug showed a statistically and clinically significant sustained effect with the three doses tested from day 1 to day 7 and had a five minutes after onset of the first administration. Trough and peak FEV1 7th significantly better than placebo at all doses tested both day 1 and day silagra wiki .

Almirall has already started discussions with potential partners for the development and commercialization collaborations on LAS100977 started.About the Surveythe multi – dose, placebo – controlled, three – period cross-over study included 20 stable asthmatic patients. All patients were on stable doses of inhaled corticosteroids. Patients were again randomized to daily treatment inhaled with one of three doses of LAS100977 or placebo received for 7 days, with a capsule inhaler. Measurements of efficacy * and safety were taken at fixed time points over 24 hours, on the first and on the last day . LAS 100,977 demonstrated 24 hours bronchodilation and sustained efficacy during multiple dose administrations with no significant increase in cardiovascular side effects. These findings corroborate the results of previous studies that Almirall investigational potent and selective with good safety and tolerability profile shown.

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