ChAd vectors make up a new-generation vaccine technology that initial reached clinical evaluation in 20073-5 and are generally used clinically with an MVA booster dosage.6-14 A single dose of 1010 or 1011 virus contaminants of chimpanzee adenovirus type 3 encoding the Zaire ebolavirus wild-type surface area glycoprotein had shown efficacy in cynomolgus macaques, which encouraged the evaluation of a single-dosage vaccine in this stage 1 trial, called EBL01.2 The Guinea outbreak strain of ebolavirus is 97 percent identical in amino acid sequence to the well-characterized Zaire strain.15 Although the initial clinical-development arrange for this Ebola vaccine included the usage of a bivalent vaccine formulation of Zaire and Sudan strains16 that could use both ChAd3 and MVA primarily for biodefense, the ChAd3 vaccine encoding just the Zaire stress were a potentially advantageous monovalent formulation for outbreak control based on efficacy data in macaques and was thus selected for testing in this study.We also plan to submit the complete study results for presentation at an upcoming medical meeting. This research generated important data regarding the protection and efficacy profile for FOLOTYN in advanced non-small cell lung cancers, a location of high unmet medical need, stated Paul L. Berns, chief executive officer at Allos Therapeutics. We believe these data warrant additional analysis to look for the future development strategy based on our assessment of the potential medical, regulatory and commercial opportunities for FOLOTYN in this indication. .
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